Our partners

KARISMA FACE Rh COLLAGEN® in Dubai

Recombinant human collagen for skin quality.

Karisma Face Rh Collagen® is an injectable bio-restitutive treatment designed to support skin quality, firmness and tissue structure through a combination of recombinant Type I collagen components, high-molecular-weight hyaluronic acid and carboxymethyl cellulose (CMC).

  • Recombinant human collagen
  • Natural-looking change
  • Supports skin quality
  • Doctor-led assessment
A woman beside the Karisma Face Rh Collagen carton

What Can Karisma Rh Collagen® Address?

  • SKIN QUALITY
    • Loss of Skin Firmness
    • Reduced Elasticity
    • Fine Lines
    • Crepey-Looking Skin
    • Uneven Skin Texture
    • Dull or Tired-Looking Skin
    • Age-Related Skin Changes
  • FACIAL SKIN
    • Cheeks
    • Lower Face
    • Jawline Area
    • Selected Facial Areas According to Assessment
  • BIO-RESTORATIONKarisma may be considered when the treatment objective is:
    • Collagen Support
    • Improved Skin Structure
    • Improved Firmness
    • Improved Tissue Quality
    • Hydration Support
    • Progressive Skin Revitalisation

About this treatment

Composition
Recombinant collagen-related component + high-molecular-weight HA + CMC
Areas
Face • Cheeks • Lower Face • Jawline • Skin Quality
Results
progressive rather than dramatic immediate results
Sessions
no universal treatment course appropriate for every patient

How Does Karisma Rh Collagen® Work?

  1. Recombinant collagen: a collagen helix with the formulation's purity and stability noted beside it
    01

    RECOMBINANT COLLAGEN

    Karisma contains an R-polypeptide α1 chain of Type I collagen. The recombinant component is designed to support processes associated with endogenous collagen synthesis.

  2. Targeted delivery: a needle placing the product into the mid to deep dermis
    02

    FIBROBLAST SUPPORT

    The formulation is designed to support fibroblast activity. Fibroblasts are key cells involved in maintaining and producing components of the dermal extracellular matrix.

  3. Stimulation of regeneration: fibroblasts activated within the dermis
    03

    TYPE I COLLAGEN SUPPORT

    The treatment is designed to promote endogenous Type I collagen production.

  4. Collagen formation and remodelling: new fibres forming through the dermal layer
    04

    HYALURONIC ACID & EXTRACELLULAR ENVIRONMENT

    High-molecular-weight hyaluronic acid contributes to tissue hydration and the extracellular environment in which collagen fibres and dermal cells function.

  5. Long-term regeneration: sustained support through the dermal structure
    05

    PROGRESSIVE SKIN QUALITY IMPROVEMENT

    Rather than creating aggressive facial volume, the treatment is intended to progressively improve: Firmness • Structure • Elasticity • Hydration • Overall Skin Quality

Rh CollagenFibroblast SupportType I CollagenImproved Dermal StructureProgressive Skin Quality

The Three Components of Karisma

  • Recombinant Rh Collagen®The collagen component differentiates Karisma from treatments that stimulate collagen through other injectable materials. The recombinant Type I collagen-related component is incorporated into the formulation with the objective of supporting endogenous collagen processes.
  • High-Molecular-Weight Hyaluronic AcidHyaluronic acid is naturally present within the extracellular matrix. In the Karisma formulation, high-molecular-weight HA contributes to: Tissue Hydration • Extracellular Environment • Organisation Around Collagen Fibres • Overall Skin Quality The objective here is different from using a cross-linked HA filler to create significant projection or facial contour.
  • Carboxymethyl Cellulose — CMCCMC is another component of the Karisma formulation and contributes to its characteristics within the tissue.

For the patient, the important message is simple: Karisma is a combined bio-restitutive formulation — not simply “a syringe of collagen”.

Benefits of Karisma Rh Collagen®

  • Supports Type I CollagenThe formulation is designed to support processes associated with endogenous Type I collagen production and dermal structure.
  • Focuses on Skin QualityKarisma is selected when the main objective is improvement in: Firmness • Elasticity • Texture • Hydration • Overall Skin Quality rather than significant facial augmentation.
  • Bio-Restorative ApproachThe combination of recombinant collagen-related components, high-molecular-weight hyaluronic acid and CMC is designed to support the biological environment of the skin.
  • Progressive ResultsKarisma is intended to produce gradual changes in skin quality rather than dramatic immediate volume.
  • Natural-Looking RejuvenationThe treatment may be particularly relevant for patients who want to improve the condition of their skin without significantly changing facial proportions.
  • Personalised TreatmentKarisma may be used alone or incorporated into a broader skin-quality and facial-rejuvenation programme when medically appropriate.

Ideal for Patients Who Want

  • Healthier, firmer-looking skin
  • Improved texture and elasticity
  • Natural improvement without changing facial proportions
  • A gradual, bio-restorative approach to rejuvenation

What Happens During Karisma Rh Collagen® Treatment?

  1. Medical Consultation

    The doctor assesses: Skin Quality • Firmness • Elasticity • Texture • Facial Anatomy • Volume Distribution • Degree of Laxity • Previous Injectable Treatments

  2. Treatment Planning

    We determine whether the primary concern is skin quality or whether another issue — such as structural volume loss, muscular activity or significant laxity — requires a different treatment.

  3. Injection Planning

    Treatment areas and injection technique are selected according to anatomy and individual goals.

  4. Karisma Injection

    The product is administered into selected areas using an appropriate medical injection technique.

  5. Aftercare

    The treated skin is reassessed and personalised post-treatment instructions are provided.

Karisma Rh Collagen® Recovery & Downtime

  1. Karisma is a minimally invasive injectable procedure.
    • Temporary reactions may include: Redness • Swelling • Tenderness • Bruising • Small Injection Marks • Temporary Raised Areas Depending on Injection Technique

These reactions generally settle progressively. Recovery varies according to the treatment area, technique and individual response.

  • Who May Be a Good Candidate?

    • Early loss of skin firmness
    • Reduced skin elasticity
    • Fine lines related to skin-quality changes
    • Crepey-looking skin
    • Dull, tired-looking skin
    • Early age-related changes
    • Patients wanting improvement without significant volumisation
  • When Might We Recommend Something Else?

    • Significant volume restoration needed
    • Advanced tissue laxity
    • Muscle-driven wrinkles
    • Pigmentation or vascular concerns
    • No meaningful indication

Not every patient asking for “collagen” needs a collagen injectable.

How Karisma Compares

KARISMA Rh COLLAGEN®Skin Quality • Firmness • Bio-Restoration
SCULPTRA® (PLLA-SCA)Collagen Stimulation • Structural Support
RADIESSE® (CaHA)Structural Support • Contour • Biostimulation
HA FILLERS (JUVÉDERM®, STYLAGE®, BELOTERO®)Volume • Shape • Projection • Contour

Different biology. Different targets. Different results.

Possible Side Effects & Considerations

Temporary injection-related reactions may include: Redness • Swelling • Tenderness • Bruising • Injection-Site Sensitivity

Other adverse effects are possible with injectable procedures.

Appropriate medical assessment, anatomical knowledge, injection technique and patient selection are important.

Medical history, medications, allergies, previous injectable treatments and individual risk factors should be reviewed before treatment.

Read more about Karisma Rh Collagen®

Karisma Face Rh Collagen® is an injectable bio-restitutive treatment designed to support skin quality, firmness and tissue structure through a combination of recombinant Type I collagen components, high-molecular-weight hyaluronic acid and carboxymethyl cellulose (CMC).

Unlike traditional dermal fillers, the primary objective of Karisma is not to create significant facial volume or change facial proportions.

At Pearl Skin Polyclinic in Dubai, Karisma is selected for patients whose main concern is the quality and biological condition of the skin rather than simply volume loss.

The goal is not to fill the face. The goal is to support the skin's structure, firmness and regenerative environment.

What Is Karisma Face Rh Collagen®?

Karisma Face Rh Collagen® is an injectable formulation based on three principal components:

A cross section of skin with collagen support labelled beside it
  • Recombinant Type I Collagen α1-ChainA recombinant R-polypeptide α1 chain related to Type I collagen.
  • High-Molecular-Weight Hyaluronic AcidHyaluronic acid contributes to the extracellular environment and tissue hydration.
  • Carboxymethyl Cellulose — CMCCMC contributes to the physical and biological characteristics of the formulation.

These components work together rather than acting as three unrelated ingredients.

What Makes Karisma Different?

  • KARISMA Rh COLLAGEN®Primary focus: Skin Quality + Bio-Restoration + Type I Collagen Support
  • HYALURONIC ACID FILLERPrimary focus: Volume + Shape + Projection + Contour
  • RADIESSE®Primary focus: CaHA Structural Support + Biostimulation
  • SCULPTRA®Primary focus: PLLA Collagen Stimulation + Progressive Structural Change

None is universally “better”. They solve different biological and anatomical problems.

Karisma Rh Collagen® for Skin Laxity

Skin laxity can have several causes.

These include changes in: Collagen • Elastin • Extracellular Matrix • Facial Fat • Ligaments • Bone Structure • Skin Thickness

Karisma may be considered when skin quality and early tissue laxity are important components.

However, an injectable skin-quality treatment cannot correct every degree of laxity.

Patients with more significant tissue laxity may require another strategy, such as Morpheus8 or other treatments depending on anatomy.

We first determine whether the problem is skin quality or structural ptosis.

Karisma Rh Collagen® for Fine Lines & Texture

Fine lines are not always caused by the same mechanism.

Some are dynamic and related to muscle movement.

Others are associated with: Collagen Changes • Dehydration • Photodamage • Reduced Elasticity • Changes in Dermal Quality

When reduced skin quality is an important component, Karisma may form part of the treatment strategy.

It does not replace botulinum toxin for muscle-driven wrinkles and does not replace filler when true structural volume is missing.

Karisma Rh Collagen® for Natural-Looking Rejuvenation

SKIN QUALITY BEFORE VOLUME

Many patients do not want larger cheeks, a sharper jawline or obvious facial augmentation.

They simply feel that their skin has become:

Thinner • Less Firm • Less Elastic • More Tired-Looking

For these patients, improving tissue quality may be more appropriate than simply adding another syringe of filler.

Karisma Rh Collagen® for the Face

Cheeks, lower face and jawline labelled on a three quarter view of a face

Facial skin may gradually develop: Reduced Firmness • Fine Lines • Crepey Texture • Dullness • Reduced Elasticity • Changes in Overall Skin Quality

Karisma may be considered when these changes are associated with declining dermal quality rather than a significant structural volume deficit.

Treatment areas are selected according to anatomy and skin condition.

The objective is bio-restoration of the skin rather than facial reshaping.

Karisma Rh Collagen® for Cheeks

The cheek area may show changes in both volume and skin quality with age.

These are not the same problem.

When significant volume is missing, a dermal filler or another structural treatment may be required.

When the main concern is: Reduced Firmness • Fine Texture Changes • Reduced Elasticity • Skin Quality

Karisma may be considered as part of the treatment strategy.

We distinguish between a cheek that needs structural volume and skin that needs biological support.

Karisma Rh Collagen® for the Lower Face & Jawline

The lower face can show several age-related changes simultaneously.

These may involve: Skin Quality • Collagen Loss • Reduced Firmness • Tissue Laxity • Facial Volume • Muscular Activity

Karisma may be considered when reduced skin quality and early laxity are important components.

However, it is not intended to create the same projection or contour as a structural jawline filler.

It also does not replace treatment for significant tissue descent.

Karisma Rh Collagen® for the Periorbital Area

The skin around the eyes is thin and may show collagen-related changes relatively early.

Selected patients may present with: Fine Lines • Crepey Texture • Reduced Elasticity • Thin-Looking Skin • Early Age-Related Changes

When skin quality is the dominant concern, a collagen-supporting treatment may be considered following assessment.

However, under-eye concerns can also result from: Tear-Trough Hollowing • Pigmentation • Visible Vessels • Fluid Retention • Eye Bags

These require different treatment strategies.

Not every tired-looking eye area needs filler — and not every under-eye concern is a skin-quality problem.

Karisma Rh Collagen® vs Dermal Fillers

Karisma and hyaluronic acid dermal fillers are injectable treatments with different primary objectives.

  • KARISMA Rh COLLAGEN®Primarily focuses on:
    • Skin Quality
    • Bio-Restoration
    • Type I Collagen Support
    • Firmness
    • Elasticity
  • HYALURONIC ACID FILLERSPrimarily focus on:
    • Volume
    • Shape
    • Projection
    • Facial Contouring
    • Structural Correction

A patient may have good facial volume but reduced skin quality. Another patient may have true structural volume loss. These patients should not automatically receive the same treatment.

Karisma Rh Collagen® vs Sculptra®

Both treatments can be discussed within regenerative aesthetic medicine, but they use different formulations and treatment concepts.

Karisma Rh Collagen® combines a recombinant Type I collagen-related component, high-molecular-weight hyaluronic acid and CMC, with a primary focus on skin quality and bio-restoration.

Sculptra® contains poly-L-lactic acid (PLLA) and is primarily used for progressive collagen stimulation and structural tissue support.

Sculptra® may be more appropriate when age-related structural changes and loss of facial support are important.

Karisma may be selected when skin quality, firmness and dermal condition are the primary targets.

Karisma Rh Collagen® vs RADIESSE®

RADIESSE® contains calcium hydroxylapatite (CaHA) and can provide structural support together with biostimulation.

Karisma has a different composition and treatment concept.

Karisma Rh Collagen®: Recombinant collagen-related component + high-molecular-weight HA + CMC.

Primary focus: Skin Quality & Bio-Restoration

RADIESSE®: CaHA microspheres + gel carrier.

Primary focus depends on technique and may include Structural Support & Biostimulation.

The appropriate injectable is selected according to the tissue and treatment objective.

Karisma Rh Collagen® vs Skin Boosters

Skin boosters are a broad category of injectable treatments designed primarily to improve skin quality.

Different products may focus on: Hydration • Elasticity • Fine Lines • Skin Texture • Regenerative Support

Karisma differs through its specific formulation containing a recombinant Type I collagen-related component together with high-molecular-weight hyaluronic acid and CMC.

Treatment should therefore be selected according to the patient's skin rather than treating every injectable skin-quality product as interchangeable.

Karisma Rh Collagen® vs Morpheus8

Karisma and Morpheus8 can both be considered when skin quality is a concern, but they work differently.

Karisma is an injectable bio-restorative treatment.

Morpheus8 combines microneedles with radiofrequency energy to create controlled fractional tissue remodelling.

Morpheus8 may be more appropriate when the primary concerns include: More Significant Skin Laxity • Acne Scars • Deeper Texture Changes • Fractional Tissue Remodelling

Karisma may be considered when the primary goal is: Skin Quality • Fine Lines • Firmness • Elasticity • Bio-Restoration

Some patients may benefit from both treatments within a staged programme.

Who Is Karisma Rh Collagen® For?

Karisma may be considered for selected adults concerned about:

  • Reduced Skin Firmnesswhen the skin feels less supported or resilient.
  • Reduced Elasticityage-related changes in skin flexibility and quality.
  • Fine Lineswhen dermal quality contributes to superficial lines.
  • Crepey-Looking Skinselected areas showing fine textural changes.
  • Uneven Skin Texturewhen improvement in overall dermal quality is appropriate.
  • Dull or Tired-Looking Skinwhen skin revitalisation is the treatment objective.
  • Early Skin Laxitywhen reduced skin quality rather than significant structural ptosis is the main concern.
  • Natural-Looking Rejuvenationfor patients who want to improve skin quality without significant facial augmentation.

When Will I See Karisma Results?

Karisma is designed to produce progressive rather than dramatic immediate results.

Temporary changes related to the injection itself may be visible immediately after treatment.

The skin-quality response develops progressively.

Depending on individual response, patients may notice changes in: Firmness • Elasticity • Texture • Hydration • Fine Lines • Overall Skin Appearance

The final result should therefore not be judged immediately after injection.

How Many Karisma Sessions Will I Need?

There is no universal treatment course appropriate for every patient.

The treatment plan depends on: Age • Skin Quality • Degree of Collagen-Related Change • Treatment Area • Previous Treatments • Individual Response • Treatment Goals

A course of treatments may be recommended according to medical assessment and the manufacturer's appropriate protocol.

Maintenance treatment may also be considered according to individual skin condition.

Karisma Rh Collagen® Aftercare

Patients should follow the individual instructions provided by their doctor.

Depending on the treatment area and technique, patients may be advised to temporarily avoid: Intense Exercise • Sauna • Steam Rooms • Excessive Heat • Swimming • Aggressive Skincare • Pressure or Manipulation of Treated Areas

Strong acids, retinoids or aggressive exfoliation may need to be temporarily paused according to medical advice.

Do not massage or manipulate injection sites unless specifically instructed.

Can Karisma Be Combined with Other Treatments?

Karisma may form part of a broader personalised skin-rejuvenation programme.

Depending on the patient's concerns, this may include selected combinations with: BOTOX® / Dysport® • Dermal Fillers • Sculptra® • RADIESSE® • Morpheus8 • BBL HEROic™ • HELEO4™ • Other Skin-Quality Treatments

These treatments address different biological or structural targets.

They are not necessarily performed during the same appointment.

The sequence and timing should be planned individually.

When Karisma May Not Be the Right Treatment

Karisma is not intended to correct every aesthetic concern.

Another treatment may be more appropriate when the primary problem is:

Significant Facial Volume Loss • Need for High-Projection Contouring • Dynamic Wrinkles • Significant Skin Laxity • Deep Acne Scars • Pigmentation • Vascular Redness • Significant Under-Eye Bags or Structural Hollowing

Correct treatment begins with determining whether the concern originates primarily from: Skin Quality • Collagen Loss • Volume • Muscle Activity • Pigmentation • Vascularity • Structural Laxity

Karisma Face Rh Collagen® Consultation in Dubai

At Pearl Skin Polyclinic in Dubai, Karisma treatment begins with determining whether the main problem is skin quality rather than simply volume loss.

We assess firmness, elasticity, texture, facial anatomy, existing volume, degree of laxity and previous aesthetic treatments.

Karisma may be recommended when a recombinant Type I collagen-based bio-restorative approach corresponds to the patient's skin condition and treatment goals.

For patients with structural volume loss, significant laxity, muscle-driven wrinkles or other concerns, another treatment may be more appropriate.

The goal is progressive improvement in skin structure, firmness and quality while preserving natural facial proportions.

Ready to restore skin quality naturally?

Book a personalised consultation with our doctors.

Paulina assistant
Medical Aesthetics · Dubai