Karisma Face Rh Collagen® is an injectable bio-restitutive treatment designed to support skin quality, firmness and tissue structure through a combination of recombinant Type I collagen components, high-molecular-weight hyaluronic acid and carboxymethyl cellulose (CMC).
BIO-RESTORATIONKarisma may be considered when the treatment objective is:
Collagen Support
Improved Skin Structure
Improved Firmness
Improved Tissue Quality
Hydration Support
Progressive Skin Revitalisation
About this treatment
Composition
Recombinant collagen-related component + high-molecular-weight HA + CMC
Areas
Face • Cheeks • Lower Face • Jawline • Skin Quality
Results
progressive rather than dramatic immediate results
Sessions
no universal treatment course appropriate for every patient
How Does Karisma Rh Collagen® Work?
01
RECOMBINANT COLLAGEN
Karisma contains an R-polypeptide α1 chain of Type I collagen. The recombinant component is designed to support processes associated with endogenous collagen synthesis.
02
FIBROBLAST SUPPORT
The formulation is designed to support fibroblast activity. Fibroblasts are key cells involved in maintaining and producing components of the dermal extracellular matrix.
03
TYPE I COLLAGEN SUPPORT
The treatment is designed to promote endogenous Type I collagen production.
04
HYALURONIC ACID & EXTRACELLULAR ENVIRONMENT
High-molecular-weight hyaluronic acid contributes to tissue hydration and the extracellular environment in which collagen fibres and dermal cells function.
05
PROGRESSIVE SKIN QUALITY IMPROVEMENT
Rather than creating aggressive facial volume, the treatment is intended to progressively improve: Firmness • Structure • Elasticity • Hydration • Overall Skin Quality
Rh Collagen→Fibroblast Support→Type I Collagen→Improved Dermal Structure→Progressive Skin Quality
The Three Components of Karisma
Recombinant Rh Collagen®The collagen component differentiates Karisma from treatments that stimulate collagen through other injectable materials. The recombinant Type I collagen-related component is incorporated into the formulation with the objective of supporting endogenous collagen processes.
High-Molecular-Weight Hyaluronic AcidHyaluronic acid is naturally present within the extracellular matrix. In the Karisma formulation, high-molecular-weight HA contributes to: Tissue Hydration • Extracellular Environment • Organisation Around Collagen Fibres • Overall Skin Quality The objective here is different from using a cross-linked HA filler to create significant projection or facial contour.
Carboxymethyl Cellulose — CMCCMC is another component of the Karisma formulation and contributes to its characteristics within the tissue.
For the patient, the important message is simple: Karisma is a combined bio-restitutive formulation — not simply “a syringe of collagen”.
Benefits of Karisma Rh Collagen®
Supports Type I CollagenThe formulation is designed to support processes associated with endogenous Type I collagen production and dermal structure.
Focuses on Skin QualityKarisma is selected when the main objective is improvement in: Firmness • Elasticity • Texture • Hydration • Overall Skin Quality rather than significant facial augmentation.
Bio-Restorative ApproachThe combination of recombinant collagen-related components, high-molecular-weight hyaluronic acid and CMC is designed to support the biological environment of the skin.
Progressive ResultsKarisma is intended to produce gradual changes in skin quality rather than dramatic immediate volume.
Natural-Looking RejuvenationThe treatment may be particularly relevant for patients who want to improve the condition of their skin without significantly changing facial proportions.
Personalised TreatmentKarisma may be used alone or incorporated into a broader skin-quality and facial-rejuvenation programme when medically appropriate.
Ideal for Patients Who Want
Healthier, firmer-looking skin
Improved texture and elasticity
Natural improvement without changing facial proportions
A gradual, bio-restorative approach to rejuvenation
What Happens During Karisma Rh Collagen® Treatment?
1
Medical Consultation
The doctor assesses: Skin Quality • Firmness • Elasticity • Texture • Facial Anatomy • Volume Distribution • Degree of Laxity • Previous Injectable Treatments
2
Treatment Planning
We determine whether the primary concern is skin quality or whether another issue — such as structural volume loss, muscular activity or significant laxity — requires a different treatment.
3
Injection Planning
Treatment areas and injection technique are selected according to anatomy and individual goals.
4
Karisma Injection
The product is administered into selected areas using an appropriate medical injection technique.
5
Aftercare
The treated skin is reassessed and personalised post-treatment instructions are provided.
Karisma Rh Collagen® Recovery & Downtime
Karisma is a minimally invasive injectable procedure.
Temporary reactions may include: Redness • Swelling • Tenderness • Bruising • Small Injection Marks • Temporary Raised Areas Depending on Injection Technique
These reactions generally settle progressively. Recovery varies according to the treatment area, technique and individual response.
Who May Be a Good Candidate?
Early loss of skin firmness
Reduced skin elasticity
Fine lines related to skin-quality changes
Crepey-looking skin
Dull, tired-looking skin
Early age-related changes
Patients wanting improvement without significant volumisation
When Might We Recommend Something Else?
Significant volume restoration needed
Advanced tissue laxity
Muscle-driven wrinkles
Pigmentation or vascular concerns
No meaningful indication
Not every patient asking for “collagen” needs a collagen injectable.
How Karisma Compares
KARISMA Rh COLLAGEN®
→Skin Quality • Firmness • Bio-Restoration
SCULPTRA® (PLLA-SCA)
→Collagen Stimulation • Structural Support
RADIESSE® (CaHA)
→Structural Support • Contour • Biostimulation
HA FILLERS (JUVÉDERM®, STYLAGE®, BELOTERO®)
→Volume • Shape • Projection • Contour
Different biology. Different targets. Different results.
Other adverse effects are possible with injectable procedures.
Appropriate medical assessment, anatomical knowledge, injection technique and patient selection are important.
Medical history, medications, allergies, previous injectable treatments and individual risk factors should be reviewed before treatment.
Read more about Karisma Rh Collagen®
Karisma Face Rh Collagen® is an injectable bio-restitutive treatment designed to support skin quality, firmness and tissue structure through a combination of recombinant Type I collagen components, high-molecular-weight hyaluronic acid and carboxymethyl cellulose (CMC).
Unlike traditional dermal fillers, the primary objective of Karisma is not to create significant facial volume or change facial proportions.
At Pearl Skin Polyclinic in Dubai, Karisma is selected for patients whose main concern is the quality and biological condition of the skin rather than simply volume loss.
The goal is not to fill the face. The goal is to support the skin's structure, firmness and regenerative environment.
What Is Karisma Face Rh Collagen®?
Karisma Face Rh Collagen® is an injectable formulation based on three principal components:
Recombinant Type I Collagen α1-ChainA recombinant R-polypeptide α1 chain related to Type I collagen.
High-Molecular-Weight Hyaluronic AcidHyaluronic acid contributes to the extracellular environment and tissue hydration.
Carboxymethyl Cellulose — CMCCMC contributes to the physical and biological characteristics of the formulation.
These components work together rather than acting as three unrelated ingredients.
What Makes Karisma Different?
KARISMA Rh COLLAGEN®Primary focus: Skin Quality + Bio-Restoration + Type I Collagen Support
None is universally “better”. They solve different biological and anatomical problems.
Karisma Rh Collagen® for Skin Laxity
Skin laxity can have several causes.
These include changes in: Collagen • Elastin • Extracellular Matrix • Facial Fat • Ligaments • Bone Structure • Skin Thickness
Karisma may be considered when skin quality and early tissue laxity are important components.
However, an injectable skin-quality treatment cannot correct every degree of laxity.
Patients with more significant tissue laxity may require another strategy, such as Morpheus8 or other treatments depending on anatomy.
We first determine whether the problem is skin quality or structural ptosis.
Karisma Rh Collagen® for Fine Lines & Texture
Fine lines are not always caused by the same mechanism.
Some are dynamic and related to muscle movement.
Others are associated with: Collagen Changes • Dehydration • Photodamage • Reduced Elasticity • Changes in Dermal Quality
When reduced skin quality is an important component, Karisma may form part of the treatment strategy.
It does not replace botulinum toxin for muscle-driven wrinkles and does not replace filler when true structural volume is missing.
Karisma Rh Collagen® for Natural-Looking Rejuvenation
SKIN QUALITY BEFORE VOLUME
Many patients do not want larger cheeks, a sharper jawline or obvious facial augmentation.
They simply feel that their skin has become:
Thinner • Less Firm • Less Elastic • More Tired-Looking
For these patients, improving tissue quality may be more appropriate than simply adding another syringe of filler.
Karisma Rh Collagen® for the Face
Facial skin may gradually develop: Reduced Firmness • Fine Lines • Crepey Texture • Dullness • Reduced Elasticity • Changes in Overall Skin Quality
Karisma may be considered when these changes are associated with declining dermal quality rather than a significant structural volume deficit.
Treatment areas are selected according to anatomy and skin condition.
The objective is bio-restoration of the skin rather than facial reshaping.
Karisma Rh Collagen® for Cheeks
The cheek area may show changes in both volume and skin quality with age.
These are not the same problem.
When significant volume is missing, a dermal filler or another structural treatment may be required.
When the main concern is: Reduced Firmness • Fine Texture Changes • Reduced Elasticity • Skin Quality
Karisma may be considered as part of the treatment strategy.
We distinguish between a cheek that needs structural volume and skin that needs biological support.
Karisma Rh Collagen® for the Lower Face & Jawline
The lower face can show several age-related changes simultaneously.
These may involve: Skin Quality • Collagen Loss • Reduced Firmness • Tissue Laxity • Facial Volume • Muscular Activity
Karisma may be considered when reduced skin quality and early laxity are important components.
However, it is not intended to create the same projection or contour as a structural jawline filler.
It also does not replace treatment for significant tissue descent.
Karisma Rh Collagen® for the Periorbital Area
The skin around the eyes is thin and may show collagen-related changes relatively early.
Selected patients may present with: Fine Lines • Crepey Texture • Reduced Elasticity • Thin-Looking Skin • Early Age-Related Changes
When skin quality is the dominant concern, a collagen-supporting treatment may be considered following assessment.
However, under-eye concerns can also result from: Tear-Trough Hollowing • Pigmentation • Visible Vessels • Fluid Retention • Eye Bags
These require different treatment strategies.
Not every tired-looking eye area needs filler — and not every under-eye concern is a skin-quality problem.
Karisma Rh Collagen® vs Dermal Fillers
Karisma and hyaluronic acid dermal fillers are injectable treatments with different primary objectives.
KARISMA Rh COLLAGEN®Primarily focuses on:
Skin Quality
Bio-Restoration
Type I Collagen Support
Firmness
Elasticity
HYALURONIC ACID FILLERSPrimarily focus on:
Volume
Shape
Projection
Facial Contouring
Structural Correction
A patient may have good facial volume but reduced skin quality. Another patient may have true structural volume loss. These patients should not automatically receive the same treatment.
Karisma Rh Collagen® vs Sculptra®
Both treatments can be discussed within regenerative aesthetic medicine, but they use different formulations and treatment concepts.
Karisma Rh Collagen® combines a recombinant Type I collagen-related component, high-molecular-weight hyaluronic acid and CMC, with a primary focus on skin quality and bio-restoration.
Sculptra® contains poly-L-lactic acid (PLLA) and is primarily used for progressive collagen stimulation and structural tissue support.
Sculptra® may be more appropriate when age-related structural changes and loss of facial support are important.
Karisma may be selected when skin quality, firmness and dermal condition are the primary targets.
Karisma Rh Collagen® vs RADIESSE®
RADIESSE® contains calcium hydroxylapatite (CaHA) and can provide structural support together with biostimulation.
Karisma has a different composition and treatment concept.
Primary focus depends on technique and may include Structural Support & Biostimulation.
The appropriate injectable is selected according to the tissue and treatment objective.
Karisma Rh Collagen® vs Skin Boosters
Skin boosters are a broad category of injectable treatments designed primarily to improve skin quality.
Different products may focus on: Hydration • Elasticity • Fine Lines • Skin Texture • Regenerative Support
Karisma differs through its specific formulation containing a recombinant Type I collagen-related component together with high-molecular-weight hyaluronic acid and CMC.
Treatment should therefore be selected according to the patient's skin rather than treating every injectable skin-quality product as interchangeable.
Karisma Rh Collagen® vs Morpheus8
Karisma and Morpheus8 can both be considered when skin quality is a concern, but they work differently.
Karisma is an injectable bio-restorative treatment.
Morpheus8 combines microneedles with radiofrequency energy to create controlled fractional tissue remodelling.
Morpheus8 may be more appropriate when the primary concerns include: More Significant Skin Laxity • Acne Scars • Deeper Texture Changes • Fractional Tissue Remodelling
Karisma may be considered when the primary goal is: Skin Quality • Fine Lines • Firmness • Elasticity • Bio-Restoration
Some patients may benefit from both treatments within a staged programme.
Who Is Karisma Rh Collagen® For?
Karisma may be considered for selected adults concerned about:
Reduced Skin Firmnesswhen the skin feels less supported or resilient.
Reduced Elasticityage-related changes in skin flexibility and quality.
Fine Lineswhen dermal quality contributes to superficial lines.
Crepey-Looking Skinselected areas showing fine textural changes.
Uneven Skin Texturewhen improvement in overall dermal quality is appropriate.
Dull or Tired-Looking Skinwhen skin revitalisation is the treatment objective.
Early Skin Laxitywhen reduced skin quality rather than significant structural ptosis is the main concern.
Natural-Looking Rejuvenationfor patients who want to improve skin quality without significant facial augmentation.
When Will I See Karisma Results?
Karisma is designed to produce progressive rather than dramatic immediate results.
Temporary changes related to the injection itself may be visible immediately after treatment.
The skin-quality response develops progressively.
Depending on individual response, patients may notice changes in: Firmness • Elasticity • Texture • Hydration • Fine Lines • Overall Skin Appearance
The final result should therefore not be judged immediately after injection.
How Many Karisma Sessions Will I Need?
There is no universal treatment course appropriate for every patient.
The treatment plan depends on: Age • Skin Quality • Degree of Collagen-Related Change • Treatment Area • Previous Treatments • Individual Response • Treatment Goals
A course of treatments may be recommended according to medical assessment and the manufacturer's appropriate protocol.
Maintenance treatment may also be considered according to individual skin condition.
Karisma Rh Collagen® Aftercare
Patients should follow the individual instructions provided by their doctor.
Depending on the treatment area and technique, patients may be advised to temporarily avoid: Intense Exercise • Sauna • Steam Rooms • Excessive Heat • Swimming • Aggressive Skincare • Pressure or Manipulation of Treated Areas
Strong acids, retinoids or aggressive exfoliation may need to be temporarily paused according to medical advice.
Do not massage or manipulate injection sites unless specifically instructed.
Can Karisma Be Combined with Other Treatments?
Karisma may form part of a broader personalised skin-rejuvenation programme.
Depending on the patient's concerns, this may include selected combinations with: BOTOX® / Dysport® • Dermal Fillers • Sculptra® • RADIESSE® • Morpheus8 • BBL HEROic™ • HELEO4™ • Other Skin-Quality Treatments
These treatments address different biological or structural targets.
They are not necessarily performed during the same appointment.
The sequence and timing should be planned individually.
When Karisma May Not Be the Right Treatment
Karisma is not intended to correct every aesthetic concern.
Another treatment may be more appropriate when the primary problem is:
Significant Facial Volume Loss • Need for High-Projection Contouring • Dynamic Wrinkles • Significant Skin Laxity • Deep Acne Scars • Pigmentation • Vascular Redness • Significant Under-Eye Bags or Structural Hollowing
Correct treatment begins with determining whether the concern originates primarily from: Skin Quality • Collagen Loss • Volume • Muscle Activity • Pigmentation • Vascularity • Structural Laxity
Karisma Face Rh Collagen® Consultation in Dubai
At Pearl Skin Polyclinic in Dubai, Karisma treatment begins with determining whether the main problem is skin quality rather than simply volume loss.
We assess firmness, elasticity, texture, facial anatomy, existing volume, degree of laxity and previous aesthetic treatments.
Karisma may be recommended when a recombinant Type I collagen-based bio-restorative approach corresponds to the patient's skin condition and treatment goals.
For patients with structural volume loss, significant laxity, muscle-driven wrinkles or other concerns, another treatment may be more appropriate.
The goal is progressive improvement in skin structure, firmness and quality while preserving natural facial proportions.
Ready to restore skin quality naturally?
Book a personalised consultation with our doctors.